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<br>These tails are subject to several post-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). The [exception](https://www.mumudad.top/hughkroger726/9562934/wiki/Journal+Of+Ovarian+Research) to the rule is the DOT1 household, members of which methylate K79 in the globular area of histone H3 and that are structurally not associated to SET-area proteins 4 - 6 Current work suggests that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later) |
