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The value of creating in depth, tissue-particular maps of protein lysine acetylation websites is additional underscored by the significant role of posttranslational modifications in the evolution and phenotypic composition of vertebrates, as indicated by the significant selective stress gene regulatory elements near posttranslational-modifying enzymes have come below in placental animals ( Lowe et al. Here is more in regards to [legal practice](https://git.gestio365.com/adelaidedownin) have a look at our web-site. , 2011 ). Here, we mixed an environment friendly methodology for protein extraction from tissue samples with lysine-acetylated peptide immunoprecipitation and excessive-accuracy tandem mass spectrometric (MS/MS) measurements, which allowed us to generate an atlas of lysine acetylation websites in 16 totally different rat tissues. |
